Pathobiology of Aging & Age-related Diseases Co-Editor Jan Vijg is one of the organizers of the Molecular Basis of Aging and Dying conference to be held 14-18 September in Suzhou, China. He will be also be speaking on Genome instability in aging and disease.
Following is a selection of articles, related to topics being covered at the Molecular Basis of Aging and Dying conference, accessible in the current volume of Pathobiology of Aging & Age-related Diseases:
Geropathology Research Network Symposium 2015 – 1 July 2015
Geriatric scientists and pathologists convened in Seattle, WA, on May 7 and 8, 2015, for the first annual symposium of the Geropathology Research Network. The network is a newly formed consortium (Fig. 1) supported by the United States National Institutes of Health (NIH). The mission of the network is to develop ways to translationally enhance the level, scope, and consistency of molecular and anatomic pathology assessment in old animals involved in aging studies using a network of pathologists and scientists with expertise in the pathobiology of aging. Continue reading.
The emerging role of senescent cells in tissue homeostasis and pathophysiology – 19 May 2015
Cellular senescence is a state of permanent growth arrest and is thought to play a pivotal role in tumor suppression. Cellular senescence may play an important role in tumor suppression, wound healing, and protection against tissue fibrosis in physiological conditions in vivo. However, accumulating evidence that senescent cells may have harmful effects in vivo and may contribute to tissue remodeling, organismal aging, and many age-related diseases also exists. Cellular senescence can be induced by various intrinsic and extrinsic factors. Both p53/p21 and p16/RB pathways are important for irreversible growth arrest in senescent cells. Senescent cells secret numerous biologically active factors. This specific secretion phenotype by senescent cells may largely contribute to physiological and pathological consequences in organisms. Here I review the molecular basis of cell cycle arrest and the specific secretion phenotype in cellular senescence. I also summarize the current knowledge of the role of cellular senescence in vivo in physiological and pathological settings. Continue reading.
More about Jan Vijg
Dr. Vijg studies the genome and epigenome, and how they change with age. He is the Chair of the Department of Genetics and a professor of Genetics, and Ophthalmology & Visual Sciences at Albert Einstein College of Medicine.
Aging of the genome